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KMID : 1123920070210051297
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Korean Journal of Oriental Physiology and Pathology
2007 Volume.21 No. 5 p.1297 ~ p.1302
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Uncaria sinensis(OIi.) Havil Suppressendotoxin-induced Proinflammatory Responses through Blocking ERK Signaling Pathways
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Park Tai-Guang
Moon Hyung-Chul
Cho Hae-Joong
Seo Sang-Wan
Jung Won-Seok
Song Ho-Joon
Park Sung-Joo
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Abstract
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Uncaria sinensis(OIi.) Havil (USH) is used in traditional Korean medicine to treat inflammation such as amebic dysentery. In this study, we investigated the anti-inflammatory effect of USH. The water extract of USH significantly inhibits lipopolysaccharide (LPS)-induced nitrite oxide (NO), tumor necrosis factor , interleukin (IL)-6and IL-12 productions in murine peritoneal macrophages. Furthermore, USH selectively inhibited activation of the extracellular signal-regulated kinase (ERK) but not of p38 MAPK, c-Jun N-terminal kinase (JNK) and nuclear . In murine model, we found that administration of USH reduced serum levels of , IL-6 and IL-12 productions in LPS-treated mice. Our results suggest that USH exerts ant-inflammatory effects in macrophages via inhibition of ERK activation and may be a useful therapeutic approach to inflammatory diseases.
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KEYWORD
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LPS, Uncaria sinensis(OIi.) Havil, Inflammation, MAPK
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